Acute Ramelteon Treatment Maintains the Cardiac Rhythms of Rats during Non-REM Sleep

Sleep curtailment negatively affects cardiac activities and thus should be ameliorated by pharmacological methods. One of the therapeutic targets is melatonin receptors, which tune circadian rhythms. Ramelteon, a MT1/MT2 receptor agonist, has recently been developed to modulate sleep-wake To date, sleep-promoting effect ramelteon widely delineated, but whether treatment physiologically influences function not well understood. address this question, we recorded electrocardiograms, electromyograms, electrocorticograms in frontal cortex olfactory bulb unrestrained rats treated with either or vehicle. We detected vigilance states based on physiological measurements analyzed muscular activities. found that during non-rapid eye movement (non-REM) sleep, heartrate variability was maintained treatment. Analysis electromyograms confirmed neither microarousal non-REM sleep nor occupancy phasic periods REM altered ramelteon. Our results indicate remedial activity keeping may reduce dysfunction sleep.